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Assessment of the stability of the drug isolated from sulphide mineral water Novonukutskaya

Published in «Water: chemistry and ecology» № / 2019 , p. 131-136.
Heading:

 

Hutoryanskij V.A.
Hahinov V.V.
Kustova O.V.
Gorshkov A.G.

Summary:
In recent years, the antioxidant, anticancer properties of sulfane sulfur and its role as a regulator of the activity of many enzymes have been actively studied, but the balneological ef-fects of mineral waters on these processes are not discussed. A characteristic feature of Matses-tian type hydrogen sulphide sources that exhibit high balonologic activity is the presence of inor-ganic and cyclic organic sulphons. The results of the evaluation of the stability of the preparation isolated from the sulfide source Novonukutsky based on the analysis of free and polysulfide sul-fur by methods of solvent extraction are presented. Registration on the HPLC chromatograms of peaks of sulfur allotropes - S7 and S9, along with elemental sulfur is attributed to an artifact, the appearance of which may be associated with the decomposition of sulfanes during the analysis. It is shown that in addition to hydrogen sulfide, elemental sulfur and sulphons are important balne-ological components. The data obtained show that the therapeutic activity of the drug can be de-termined by a higher concentration of sulfides and polysulfides, and the contribution of molecu-lar sulfur is negligible. The decrease in the activity of the drug is associated with the oxidation of polysulfides to sulfates. The results obtained suggest that further research in this direction may make adjustments to existing ideas about the mechanism of the therapeutic action of Matsesta-type sulphide mineral waters, since the therapeutic effect of this type of mineral waters is still associated only with the presence of hydrogen sulfide and a salt matrix.

Keywords: : inorganic and organic sulfanes, HPLC, mineral waters, sulfur allotropes

Bibliographic link:
Hutoryanskij V.A. , Hahinov V.V., Kustova O.V. , Gorshkov A.G. Assessment of the stability of the drug isolated from sulphide mineral water Novonukutskaya // Water: chemistry and ecology. — 2019. — № . — c. 131-136. — http://watchemec.ru/en/article/29795/

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